As one of the five major facilities supported by MLSC/CTA, Michigan Center for Structural Biology (MCSB), based at Michigan State University, provides a platform of state-of-the-art instrumentation to examine the structure-function relationships of biomacromolecules. The biomolecular nuclear magnetic resonance (NMR) facility includes a group of instruments at Michigan State University, University of Michigan, and Wayne State University for both solution and solid state biomolecular NMR. In addition to the state-of-the-art NMR instrumentation, the state of Michigan has substantial expertise in the development of both solution and solid state NMR methodologies and their applications in biomolecular NMR. The instruments at individual institutions are operated by local NMR groups following the policies and rates established by a statewide NMR committee approved by MLSC/CTA. NMR time and service are generally scheduled on a monthly basis. A general description of sample requirements for NMR analysis can be found here. For more information on facility usage and services, please contact Dr. Aizhuo Liu, the Director of Biomolecular NMR Facility at Michigan State University.

Together with X-ray crystallography, NMR spectroscopy is one of the two leading technologies for the structure determination of biomacromolecules at atomic resolution. In addition, NMR provides unique and important molecular motional and interaction profiles that contain pivotal information on the functions of biomacromolecules. The information is not only important for the understanding of life processes at the molecular level but also for drug development.